Christopher G. Mayne

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Currently: Principal Scientist, Computational Chemistry, Loxo Oncology @ Lilly

Research Programmer
NIH Center for Macromolecular Modeling and Bioinformatics

Address:
Beckman Institute, Room 3011
University of Illinois at Urbana-Champaign
M/C 251
405 N. Mathews Ave.
Urbana, IL 61801

Telephone:
(217) 300-6380

E-mail:

Education

Research Interests

Publications

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Fanning, S.W.; Jeselsohn, R.; Dharmarajan, V.; Mayne, C.G.; Karimi, M.; Buchwalter, G.; Houtman, R.; Toy, W.; Fowler, C.E.; Han, R.; Laine, M.; Carlson, K.E.; Martin, T.A.; Nowak, J.; Nwachukwu, J.C.; Hosfield, D.J.; Chandarlapaty, S.; Tajkhorshid, E.; Nettles, K.W.; Griffin, P.R.; Shen, Y.; Katzenellenbogen, J.A.; Brown, M.; Greene, G.L. (2018) The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. eLife, 7, e37161. (Accompanied by a "Related Insight" article)

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Sharma, A.; Toy, W.; Guillen, V.S.; Sharma, N.; Min, J.; Carlson, K.E.; Mayne, C.G.; Lin, S.; Sabio, M.; Greene, G.; Katzenellenbogen, B.S; Chandarlapaty, S.; Katzenellenbogen, J.A. (2018) Antagonists for Constitutively Active Mutant Estrogen Receptors: Insights into the Roles of Antiestrogen-Core and Side-Chain. ACS Chem. Biol. 13(12), 3374-3384.

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Katzenellenbogen, J.A.; Mayne, C.G.; Katzenellenbogen, B.S.; Greene, G.L.; Chandarlapaty, S. (2018) Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance. Nat. Rev. Cancer 18, 377-388.

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Speltz, T.E.*; Mayne, C.G.*; Fanning, S.E.; Siddiqui, Z.; Tajkhorshid, E.; Greene, G.L.; Moore, T.W. (2018) A "Cross-Stitched" Peptide with Improved Helicity and Proteolytic Stability. Org. Biomol. Chem., 16, 3702-3706.

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Min, J.; Sanabria Guillen, V.; Sharma, A.; Zhao, Y.; Ziegler, Y.; Gong, P.; Mayne, C.G.; Srinivasan, S.; Kim, S-H.; Carlson, K.E.; Nettles, K.W.; Katzenellenbogen, B.S.; Katzenellenbogen, J.A. (2017) Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor (ER)-Mediated Activities in Breast Cancer Cells. J. Med. Chem., 60(14), 6321-6336.

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Arcario, M.J.; Mayne, C.G.; Tajkhorshid,E. (2017) A membrane-embedded pathway delivers general anesthetics to two interacting binding sites in the Gloeobacter violaceus Ion Channel. J. Biol. Chem., 292(23), 9480-9492. (Cover Article)

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Mayne, C.G.; Arcario, M.J.; Mahinthichaichan, P.; Baylong, J.L.; Vermaas, J.V.; Navidpour, L.; Wen, P.-C.; Thangapandian, S.; Tajkhorshid,E. (2016) The Cellular Membrane as a Mediator for Small Molecule Interaction with Membrane Proteins. BBA-Biomembranes 1858(10), 2290-2304.

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Vermaas, J.V.; Trebesch, N.; Mayne, C.G.; Thangapandian, S.; Baylon, J.; Jian, T.; Wang, Y.; Muller, M.P.; Shinn, E.; Zhao, Z.; Wen, P.-C.; Tajkhorshid,E. (2016) Microscopic Characterization of Membrane Transport Function by In Silico Modeling and Simulation. In Gregory A. Voth, editor: Methods in Enzymology, Vol 578: Computational Approaches for Studying Enzyme Mechanism Part B, MIE, UK: Academic Press, 2016, pp. 373-428.

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Madak-Erdogan, Z.; Kim, S-H.; Gong, P.; Zhao, Y.C.; Zhang, H.; Chambliss, K.L.; Carlson, K.E.; Mayne, C.G.; Shaul, P.H.; Korach, K.S.; Katzenellenbogen, J.A.; Katzenellenbogen, B.S. (2016) Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues. Sci. Signal. 9(429), ra53. (Cover Article, Journal Podcast)

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Teo, I.; Mayne, C.G.; Schulten, J; Lelièvre, T. (2016) Adaptive multilevel splitting method for molecular dynamics calculation of benzamidine-trypsin dissociation time. J. Chem. Theory Comput. 12(6), 2983-2989.

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Perilla, J.R.; Hadden, J.A.; Goh, B.C.; Mayne, C.G.; Schulten, K. (2016) All-Atom Molecular Dynamics of Virus Capsids as Drug Targets. J. Phys. Chem. Lett. 7, 1836-1844. (Cover Article)

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Liu, Y.*; Singharoy, A.*; Mayne, C.G.*; Sengupta, A.; Raghavachari, K.; Schulten, K.; Flood, A.H. (2016) Flexibility Coexists with Shape Persistence in Cyanostar Macrocycles. J. Am. Chem. Soc. 138(14), 4843-4851.

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Hosseinzadeh, P.; Mirts, E.; Pfister, T.; Gao, Y-G.; Mayne, C.G.; Robinson, H.; Tajkhorshid, E.; and Lu, Y. (2016) Enhancing Mn(II)-binding and manganese peroxidase activity in a designed cytochrome c peroxidase through fine-tuning secondary sphere interactions. Biochem. 55(10), 1494-1502.

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Speltz, T.E; Fanning, S.W.*; Mayne, C.G.*; Fowler, C.; Tajkhorshid, E.; Greene, G.L.; Moore, T.W. (2016) Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction. Angew. Chem. Int. Ed. 55, 4252. ("Hot Paper", Cover Article).

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Fanning, S.W.*; Mayne, C.G.*; Dharmarajan, V.*; Carlson, K.E.; Martin, T.A.; Novick, S.J.; Toy, W.; Green, B. Panchamukhi, S.; Katzenellenbogen, B.S.; Tajkhorshid, E.; Griffin, P.R.; Shen, Y.; Chandarlapaty, S.; Katzenellenbogen, J.A.; Greene, G.L. (2016) Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation eLife 5, e12792. (Accompanied by a "Related Insight" Article)

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Yasui, N.; Mayne, C.G.; Katzenellenbogen, J.A. (2015) Preparation of o-Fluorophenols from Nonaromatic Precursors: Mechanistic Considerations for Adaption to Fluorine-18 Radiolabeling Org. Lett. 17(22), 5540-5543.

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Durrant, J.D.; Carlson, K.E.; Martin, T.A.; Offutt, T.L.; Mayne, C.G.; Katzenellenbogen, J.A.; Amaro, R.E. (2015) Neural-Network Scoring Functions Identify Structurally Novel Estrogen-Receptor Ligands J. Chem. Inf. Model., 55(9), 1953-1961.

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Kim, S-H.; Madak-Erdogan, Z.; Bae, S-C.; Carlson, K.E.; Mayne, C.G.; Granick, S.; Katzenellenbogen, B.S.; Katzenellenbogen, J.A. (2015) Ligand Accessibility and Bioactivity of a Hormone-Dendrimer Conjugate Depend on pH and pH History J. Am. Chem. Soc., 137(32), 10326-10335.

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Singharoy, A.; Balasubramanian, V.; Liu, Y.; Mayne, C.G.; Lee, S.; Chen, C-H.; Zlotnick, A.; Schulten, K.; Flood, A.H. (2015) Macromolecular Crystallography for Synthetic Abiological Molecules: Combinding xMDFF and PHENIX for Structure Determination of Cyanostar Macrocycles J. Am. Chem. Soc., 137(27), 8810-8818.

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Aristoff, D.; Lelièvre, T.; Mayne, C.G.; Teo, I. (2015) Adaptive Multilevel Splitting in Molecular Dynamics Simulations ESAIM Proc., 48, 215-225..

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Arcario, M.J.; Mayne, C.G.; Tajkhorshid, E. (2014) Atomistic models of general anesthetics for use in in silico biological studies J. Phys. Chem. B., 118, 12075-12086..

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Mayne, C.G.; Saam, J.; Schulten, K.; Tajkhorshid, E.; Gumbart, J.C. (2013) Rapid parameterization of small molecules using the Force Field Toolkit J. Comput. Chem., 34, 2757-2770. (Cover Article, Top-Ten Most-Accessed Article 2014)

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Moore, T.W.; Mayne, C.G.; Katzenellenbogen, J.A. (2010) Not Picking Pockets: Nuclear Receptor Alternate-Site Modulators (NRASMs) Mol. Endo., 24(4), 683-695. (Cover Article)

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Zhou, H; Lee, J.H.; Mayne, C.G.; Carlson, K.E.; Katzenellenbogen, J.A. (2010) Imagine progesterone receptor in breast tumors: Synthesis and receptor binding affinity of fluoroalkyl-substituted analogs of Tanaproget J. Med. Chem., 53(8), 3349-3360.

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Walker, J.V.; Nitiss, K.C.; Jensen, L.H.; Mayne, C.G.; Hu, T.; Jensen, P.B.; Sehested, M.; Hsieh, T.; Nitiss, J.L. (2004) A Mutation in Human Topoisomerase II α Whose Expression Is Lethal in DNA Repair-deficient Yeast Cells. J. Biol. Chem., 275, 25947-25954.