Tao Jiang
Postdoctoral Research Associate
Ph.D. in Biophysics and Computational Biology
M.S. in Statistics
Address:
Beckman Institute, Room 3017
University of Illinois at Urbana-Champaign
405 N. Mathews Ave.
Urbana, IL 61801
E-mail:
Research Areas
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Biophysics and computational biology, molecular dynamics simulations, membrane proteins, transporters and channels, lipid-protein interactions. Projects I am currently working on:
- CLC Cl- channels and Cl-/H+ transporters
- TMEM16 Cl- Channel and phospholipid scramblase
- Fluoride channels and F-/H+ transporters
Honors & Awards
1st place, Best Speaker of the 2016 semi-annual CPLC/Biophysics Graduate Student/Postdoc Symposium, Urbana, IL
Graduate Student Travel Grants, awarded in 2016 by the Department of Biochemistry, UIUC
Graduate Teacher Certificate, awarded in 2015 by the Center for Teaching Excellence, UIUC
Conference Travel Awards for Graduate Students, awarded in 2015 & 2012 by Graduate College, UIUC
Citizen Scholar, awarded in 2012 by Center for Teaching Excellence, UIUC
Robert Emerson Graduate Fellowship, awarded in 2009 by Center for Biophysics and Computational Biology, UIUC
Leadership
Principle Investigator, project titled “Molecular Mechanisms of Lipid and Ion Translocation in a Phospholipid Scrambling Machinery” was awarded Illinois Blue Waters Allocation of 750,000 node-hours (with an estimated value of $465,000) in 2019, by National Center of Supercomputing Applications (NCSA) and National Science Foundation (NSF).
Co-chair, 2015 semi-annual CPLC/Biophysics Graduate Student/Postdoc Symposium, Urbana, IL
Graduate Board Member, 2013 & 2014 Provost and Graduate College Student Advisory Board, UIUC
Conference Talks
- Characterizing the Lipid Permeation Track and the Mechanism of Phospholipid Translocation in a Calcium-activated Scramblase. (2016) 14th semi-annual CPLC/Biophysics Graduate Student/Postdoc Symposium, Urbana, IL.
Functional Characterization of Calcium-activated Phospholipid Scramblase Activity of nhTMEM16. (2016) Biophysics Society 60th Annual Meeting, Los Angeles, CA.
Differential Anion Binding and Conformational Coupling Modes of CLC Transporters. (2015) Frontiers in Membrane Protein Structural Dynamics, Chicago, IL.
Anion-Coupled Proton Transporter: What Affects the Coupling. (2015) Biophysics Pecha-Kucha, Urbana, IL.
Characterization of Anion Binding and Proton Coupling in CLC Cl-/H+ Transporter. (2014) Frontiers in Membrane Protein Structural Dynamics, Chicago, IL.
Coupling of Anion Binding and Proton Transport in a CLC Cl-/H+ Antiporter. (2014) Molecular Biophysics Training Grants & Colin A Wraight Memorial Symposium, Urbana, IL.
Characterization of Anion Binding and Proton Coupling in a CLC Cl-/H+ Transporter. (2014) Center for the Physics of Living Cells (CPLC) Annual Symposium, Urbana, IL.
Publications
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T. S. Chavan, R. C. Cheng, T. Jiang, I. I. Mathews, R. A. Stein, A. Koehl, H. S. Mchaourab, E. Tajkhorshid*, and M. Maduke* (2020) Structural characterization of an intermediate reveals a unified mechanism for the CLC Cl-/H+ transport cycle. eLife, 9:e53479.
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T. Jiang, P.-C. Wen, N. Trebesch, Z. Zhao, S. Pant, K. Kapoor, M. Shekhar, E. Tajkhorshid (2019) Computational Dissection of Membrane Transport at a Microscopic Level. Trends in Biochemical Sciences, 45: 202-216.
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K. Yu*, T. Jiang*, Y. Cui, E. Tajkhorshid*, and H. C. Hartzell* (2019) A Network of Phosphatidylinositol 4,5-bisphosphate Binding Sites Regulate Gating of the Ca2+-activated Cl- Channel ANO1 (TMEM16A). Proceedings of the National Academy of Sciences USA, 116: 19952-19962.
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M. P. Muller*, T. Jiang*, C. Sun, M. Lihan, S. Pant, P. Mahinthichaichan, A. Trifan, and E. Tajkhorshid (2019) Characterization of Lipid-Protein Interactions and Lipid-mediated Modulation of MembraneProtein Function Through Molecular Simulation. Chemical Reviews, 119: 6068-6161.
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T. Jiang, H. C. Hartzell, K. Yu, E. Tajkhorshid. (2018) Molecular Mechanism of Lipid and Ion Transport in Phospholipid Scrambling. Blue Waters Annual Report Book, 254-255.
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P.-C. Wen*, P. Mahinthichaichan*, N. Trebesch, T. Jiang, Z. Zhao, E. Shinn, Y. Wang, M. Shekhar, K. Kapoor, C. K. Chan, and E. Tajkhorshid (2018) Microscopic View of Lipids and Their Diverse Biological Functions. Current Opinion in Structural Biology, 51: 177-186.
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T. Jiang, K. Yu, H. C. Hartzell*, and E. Tajkhorshid* (2017) Lipids and Ions Traverse the Membrane by the Same Physical Pathway in the nhTMEM16 Scramblase. eLife, 6:e28671.
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T. Jiang, W. Han, M. Maduke, and E. Tajkhorshid (2016) Molecular Basis for Differential Anion Binding and Proton Coupling in the Cl-/H+ Exchanger ClC-ec1. Journal of the American Chemical Society, 138(9): 3066-3075.
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C. M. Khantwal, S. J. Abraham, W. Han, T. Jiang, T. S. Chavan, R. C. Cheng, S. M. Elvington, C. W. Liu, I. I. Mathews, E. Tajkhorshid*, and M. Maduke* (2016) Revealing an outward-facing open conformational state in a CLC Cl-/H+ exchange transporter. eLife, 5:e11189.
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J. Vermaas, N. Trebesch, C. G. Mayne, S. Thangapandian, M. Shekhar, P. Mahinthichaichan, J. L. Baylon, T. Jiang, Y. Wang, M. P. Muller, E. Shinn, Z. Zhao, P.-C. Wen, and E. Tajkhorshid (2016) Microscopic Characterization of Membrane Transport Function by In Silico Modeling and Simulation. In Gregory A. Voth, editor: Methods in Enzymology, Vol 578: Computational Approaches for Studying Enzyme Mechanism Part B, MIE, UK: Academic Press, 2016, pp. 373-428.
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G. Enkavi, J. Li, P.-C. Wen, S. Thangapandian, M. Moradi, T. Jiang, W. Han, and E. Tajkhorshid (2014) A Microscopic View of the Mechanisms of Active Transport Across the Cellular Membrane. Annual Reports in Computational Chemistry, 10:77-125.